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  • © 2012

Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

  • Provides the reader interesting insights into highly infectious intracellular pathogen Coxiella burnetii, the causative agent of Q fever, summarized by several leading groups in the field
  • Includes the newest data, techniques, and methodologies that have substantially transformed our understanding of the pathogen
  • Useful for microbiologists as well as veterinarians, physicians and health authorities involved in clinical medicine, emerging disease surveillance and biodefense.

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiv
  2. Phylogenetic Diversity, Virulence and Comparative Genomics

    • Erin J. van Schaik, James E. Samuel
    Pages 13-38
  3. Lipopolysaccharide of Coxiella burnetii

    • Craig T. Narasaki, Rudolf Toman
    Pages 65-90
  4. Components of Protective Immunity

    • Guoquan Zhang, Yan Zhang, James E. Samuel
    Pages 91-104
  5. Proteome of Coxiella burnetii

    • Robert Ihnatko, Edward Shaw, Rudolf Toman
    Pages 105-130
  6. Coxiella Subversion of Intracellular Host Signaling

    • S. Kauser Hussain, Daniel E. Voth
    Pages 131-140
  7. The Coxiella burnetii Parasitophorous Vacuole

    • Eric Ghigo, María I. Colombo, Robert A. Heinzen
    Pages 141-169
  8. Coxiella burnetii Secretion Systems

    • Justin A. McDonough, Hayley J. Newton, Craig R. Roy
    Pages 171-197
  9. Role of Lipids in Coxiella burnetii Infection

    • Stacey D. Gilk
    Pages 199-213
  10. Axenic Growth of Coxiella burnetii

    • Anders Omsland
    Pages 215-229
  11. Developmental Biology of Coxiella burnetii

    • Michael F. Minnick, Rahul Raghavan
    Pages 231-248
  12. Genetic Manipulation of Coxiella burnetii

    • Paul A. Beare
    Pages 249-271
  13. Role of Innate and Adaptive Immunity in the Control of Q Fever

    • Christian Capo, Jean-Louis Mege
    Pages 273-286
  14. Immune Response and Coxiella burnetii Invasion

    • Amira Ben Amara, Yassina Bechah, Jean-Louis Mege
    Pages 287-298
  15. Antigenic Analysis for Vaccines and Diagnostics

    • Laura R. Hendrix, Chen Chen
    Pages 299-328
  16. Epidemic Q Fever in Humans in the Netherlands

    • Wim van der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever, Mirjam H. A. Hermans, Alexander C. A. P. Leenders et al.
    Pages 329-364
  17. Coxiella-like Endosymbionts

    • Jianmin Zhong
    Pages 365-379
  18. Molecular Typing of Coxiella burnetii (Q Fever)

    • Robert F. Massung, Sally J. Cutler, Dimitrios Frangoulidis
    Pages 381-396

About this book

Coxiella burnetii is the etiological agent of Q fever, a zoonotic disease found worldwide. The bacterium is a fascinating example of intracellular parasitism that has uniquely evolved to thrive in the most inhospitable of cellular compartments-the phagolysosome. Understanding how C. burnetii resists the degradative functions of this vacuole, and the host cell functions coopted for successful parasitism, are central to understanding Q fever pathogenesis. Recent achievements in glycomics and proteomics are guiding development of enhanced detection schemes for the bacterium in addition to shedding light on the host immune response to the pathogen. Several chapters survey immune functions that control or potentially exacerbate Coxiella infection and delve into correlates of protective immunity elicited by vaccination. Comparative genomics is also the foundation of chapters discussing diagnostic antigen discovery and molecular typing of the bacterium, with significance for development of new clinical, epidemiologic, and forensic tools.

Editors and Affiliations

  • Institute of Virology, Dept. of Rickettsiology, Slovak Academy of Sciences, Bratislava, Slovakia

    Rudolf Toman

  • Rocky Mountain Laboratories, Coxiella Pathogenesis Section, NIH/NIAID, Hamilton, USA

    Robert A. Heinzen

  • , Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M, College Station, USA

    James E. Samuel

  • Institut Fédératif de Recherche 48, Les Maladies Infect Transmissibles, CNRS-IRD UMR 6236, Marseille, Cedex 05, France

    Jean-Louis Mege

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access