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Role of Capsaicin in Oxidative Stress and Cancer

  • Book
  • © 2013

Overview

Editors:
  1. Sanjay K. Srivastava

    1. , Biomedical Sciences, Texas Tech Univ. Health Sciences Center, Amarillo, USA

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  • Thoroughly reviews the preventive and therapeutic effects of capsaicin in melanoma, pancreatic cancer, colon cancer, breast cancer, lung cancer, multiple myeloma and others
  • Identifies molecular and cellular targets of capsaicin and describes the role of mitochondria in capsaicin-mediated therapeutic effects
  • Benefits medical students, oncologists and cancer researchers

Part of the book series: Diet and Cancer (DICA, volume 3)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-ix
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  2. Role of Capsaicin in Cancer Prevention

    • Kartick C. Pramanik, Sanjay K. Srivastava
    Pages 1-18

  3. Role of Death Receptors Belonging to the TNF Family in Capsaicin-Induced Apoptosis of Tumor Cells

    • Giorgio Santoni, Sara Caprodossi, Valerio Farfariello, Sonia Liberati, Consuelo Amantini
    Pages 19-46

  4. Role of Capsaicin in Prostate Cancer

    • Inés Díaz-Laviada
    Pages 47-65

  5. Capsaicin and the Urinary Bladder

    • Robert S. Svatek, Rita Ghosh
    Pages 67-87

  6. Inhibition of Pancreatitis and Carcinogenesis by Capsaicin

    • Wanying Zhang, Jie Liao, Haonan Li, Allison Yang, Sanjay K. Srivastava, Guang-Yu Yang
    Pages 89-106

  7. Cytochrome P450-Dependent Modification of Capsaicinoids: Pharmacological Inactivation and Bioactivation Mechanisms

    • Christopher A. Reilly
    Pages 107-129

  8. The Cancer-Suppressing and -Promoting Actions of Capsaicin

    • Pin Ju Chueh
    Pages 131-147

  9. Oxidative Stress by Capsaicin in Cancer

    • Kartick C. Pramanik, Palika Datta, Sanjay K. Srivastava
    Pages 149-171

  10. Back Matter

    Pages 173-178
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Keywords

About this book

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Editors and Affiliations

  • , Biomedical Sciences, Texas Tech Univ. Health Sciences Center, Amarillo, USA

    Sanjay K. Srivastava

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