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  • Book
  • © 2014

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

Editors:

  1. Susan C. Frost

    1. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Robert McKenna

    1. Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Up to date reference for researchers and students in the carbonic anhydrase family
  • Contributions from internationally recognized investigators at the forefront of the carbonic anhydrase field
  • Mix of topics to reach audiences with interests across phylums

Part of the book series: Subcellular Biochemistry (SCBI, volume 75)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
    PDF

  2. Introduction

    1. Front Matter

      Pages 1-1
      PDF

    2. Overview of the Carbonic Anhydrase Family

      • Robert McKenna, Susan C. Frost
      Pages 3-5

  3. Carbonic Anhydrases: Ancient but Relevant

    1. Front Matter

      Pages 7-7
      PDF

    3. Catalytic Mechanism of α-Class Carbonic Anhydrases: CO2 Hydration and Proton Transfer

      • Christopher D. Boone, Melissa Pinard, Rob McKenna, David Silverman
      Pages 31-52

    5. Prokaryotic Carbonic Anhydrases of Earth’s Environment

      • R. Siva Sai Kumar, James G. Ferry
      Pages 77-87

    6. Carboxysomal Carbonic Anhydrases

      • Matthew S. Kimber
      Pages 89-103

    7. Carbonic Anhydrases and Their Interplay with Acid/Base-Coupled Membrane Transporters

      • Holger M. Becker, Michael Klier, Joachim W. Deitmer
      Pages 105-134

    8. Carbonic Anhydrase Related Proteins: Molecular Biology and Evolution

      • Ashok Aspatwar, Martti E. E. Tolvanen, Csaba Ortutay, Seppo Parkkila
      Pages 135-156

    11. Carbonic Anhydrase IX: Regulation and Role in Cancer

      • Martin Benej, Silvia Pastorekova, Jaromir Pastorek
      Pages 199-219

    12. Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases

      • Narges K. Tafreshi, Mark C. Lloyd, Marilyn M. Bui, Robert J. Gillies, David L. Morse
      Pages 221-254

    15. Carbonic Anhydrase Inhibitors Drug Design

      • Robert McKenna, Claudiu T. Supuran
      Pages 291-323

    16. Natural Products That Inhibit Carbonic Anhydrase

      • Sally-Ann Poulsen, Rohan A. Davis
      Pages 325-347

    17. Glaucoma and the Applications of Carbonic Anhydrase Inhibitors

      • Andrea Scozzafava, Claudiu T. Supuran
      Pages 349-359
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About this book

The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.
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Keywords

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Editors and Affiliations

  • Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, USA

    Susan C. Frost, Robert McKenna

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Bibliographic Information

  • Book Title: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

  • Editors: Susan C. Frost, Robert McKenna

  • Series Title: Subcellular Biochemistry

  • DOI: https://doi.org/10.1007/978-94-007-7359-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2014

  • Hardcover ISBN: 978-94-007-7358-5Published: 05 November 2013

  • Softcover ISBN: 978-94-024-0250-6Published: 23 August 2016

  • eBook ISBN: 978-94-007-7359-2Published: 22 October 2013

  • Series ISSN: 0306-0225

  • Series E-ISSN: 2542-8810

  • Edition Number: 1

  • Number of Pages: IX, 430

  • Number of Illustrations: 38 b/w illustrations, 37 illustrations in colour

  • Topics: Gene Function, Protein Science, Biomedicine general

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Buy it now

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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