PET Studies on Amino Acid Metabolism and Protein Synthesis

1. Front Matter

   Pages i-xiv

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2. Biochemistry and animal studies

   1. Cerebral Protein Turnover: Aspects and Problems

      • A. Lajtha, D. Dunlop, M. Banay-Schwartz

      Pages 1-17

   2. Determination of Regional Rates of Cerebral Protein Synthesis in Vivo with L-[1-¹⁴C]Leucine as the Tracer Amino Acid

      • C. Beebe Smith

      Pages 19-39

   3. Methionine Metabolism in Rat Brain

      • P. Bobillier, E. Grange, A. Gharib, M. Leclerc, N. Sarda, P. Lepetit

      Pages 41-52

   4. Protein Synthesis Studies in Rats with Methionine

      • A. M. Planas, C. Prenant, B. M. Mazoyer, S. Chadan, D. Comar, L. Digiamberardino

      Pages 53-68

3. Back Matter

   Pages 69-74

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4. PET Radiochemistry

   1. Carbon-11 Amino Acids, Labeling and Metabolites

      • Willem Vaalburg, Philip H. Elsinga, Anne M. J. Paans

      Pages 75-80

   2. Quality Control Aspects in the Preparation of [11C]-Methionine

      • Kjell Någren

      Pages 81-87

   3. Production of L-[18F]Fluoro Amino Acids for Protein Synthesis: Overview and Recent Developments in Nucleophilic Syntheses

      • C. Lemaire

      Pages 89-108

   4. Biochemistry and Evaluation of Fluoroamino Acids

      • H. H. Coenen

      Pages 109-131

5. Back Matter

   Pages 131-131

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6. Amino acid uptake modeling

   1. Kinetic Modeling of Fluorotyrosine Uptake

      • K. Wienhard, K. Herholz, H. H. Coenen, J. Rudolf, P. Kling, G. Stöcklin et al.

      Pages 133-147

   2. Kinetic Modelling of Carbon-11 Labelled Amino-Acids

      • G. Blomqvist

      Pages 149-160

   3. Carbon-11 Labeled Tyrosine as a Probe for Modelling the Protein Synthesis Rate

      • Anne M. J. Paans, Philip H. Elsinga, Willem Vaalburg

      Pages 161-174

   4. Kinetic Modelling of Carbon-11 Labelled Methionine

      • H. Lundqvist

      Pages 175-182

   5. Approaches to Quantitative Analysis of Amino Acid Transport and Metabolism

      • G.-J. Meyer, J. Van Den Hoff, W. Burchert, H. Hundeshagen

      Pages 183-196

   6. 11C-Methionine and 82Rubidium Uptake in Human Brain Tumors: Comparison of Carrier Dependent Blood-Brain Barrier Transport

      • U. Roelcke, E. W. Radü, K. L. Leenders

      Pages 197-201

7. Back Matter

   Pages 201-201

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8. Clinical applications

   1. Tracers for Clinical Evaluation of Gliomas: A Neurologist’s View

      • K. Herholz

      Pages 203-214

   2. PET Studies of Amino Acid Metabolism: Integration in Clinical Routine and Current Research on Intracranial Tumours

      • Kaj Ericson

      Pages 215-221

Parameters such as membrane transport, metabolism and protein incorporation govern the fate of amino acids in living tissue. Is it possible to use positron tomography to measure some of them, and what is their meaning in normal and pathological situations? These questions have been addressed for a long time and no satisfactory answer has yet been given.
This book, which derives from an EEC workshop organized in the frame of the Concerted Action on `PET Investigation of Cellular Regeneration and Degeneration', held in Lyon in February 1992, gives the present state of knowledge in this field based on the most recent studies. Contributions from 24 leading European and American scientists are presented and discussed in the following four parts:

• biochemistry and animal studies;
• amino acids labelling with positron emittors, quality control and metabolites measurement;
• kinetic modelling of amino acids transport, metabolism, and protein incorporation;
• clinical use of amino acids.

This book will aid and interest biochemists, radiochemists, pharmacologists, neurologists, oncologists and medical imaging scientists.

• Amino acid
• Tumor
• biochemistry
• diagnosis
• metabolism
• proteins
• tissue

• Groupe d’Imagerie Neuro-fonctionelle, Service Hospitalier Frédéric Joliot, CEA-DRIPP Orsay, et Hôpital R. Debré, Paris, France

  B. M. Mazoyer

• Max-Planck-Institute for Neurological Research, Cologne, Germany

  W. D. Heiss

• E.E.C. Concerted Action on PET Investigations of Cellular Regeneration and Degeneration, Service Hospitalier Frédéric Joliot, Hôpital d’Orsay, Orsay, France

  D. Comar

Policies and ethics