Overview
- Discusses updated design and analysis methods for biopharmaceutical clinical trials
- Includes chapters written by internationally respected authors from academia, government and industry who possess substantial hands-on experience designing and analyzing biopharmaceutical clinical trials
- Provides illustrative examples of the design and analysis of biopharmaceutical clinical trials
- Provides computer programs to facilitate the understanding and applications
Part of the book series: ICSA Book Series in Statistics (ICSABSS)
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Table of contents (12 chapters)
Keywords
About this book
The BASS book series is initially divided into three volumes addressing: 1) Design of Clinical Trials; 2) Biostatistical Analysis of Clinical Trials; and 3) Pharmaceutical Applications. Â
This book is the second of the 3-volume book series. The topics covered include: Statistical Approaches to the Meta-analysis of Randomized Clinical Trials, Collaborative Targeted Maximum Likelihood Estimation to Assess Causal Effects in Observational Studies, Generalized Tests in Clinical Trials, Discrete Time-to-event and Score-based Methods with Application to Composite Endpoint for Assessing Evidence of Disease Activity-Free , Imputing Missing Data Using a Surrogate Biomarker: Analyzing the Incidence of Endometrial Hyperplasia, Selected Statistical Issues in Patient-reported Outcomes, Network Meta-analysis, Detecting Safety Signals Among Adverse Events in Clinical Trials, Applied Meta-analysis Using R, Treatment of Missing Data in Comparative Effectiveness Research, Causal Estimands: A Common Language for Missing Data, Bayesian Subgroup Analysis with Examples, Statistical Methods in Diagnostic Devices, A Question-Based Approach to the Analysis of Safety Data, Analysis of Two-stage AdaptiveSeamless Trial Design, and Multiplicity Problems in Clinical Trials – A Regulatory Perspective.
Editors and Affiliations
Bibliographic Information
Book Title: Biopharmaceutical Applied Statistics Symposium
Book Subtitle: Volume 2 Biostatistical Analysis of Clinical Trials
Editors: Karl E. Peace, Ding-Geng Chen, Sandeep Menon
Series Title: ICSA Book Series in Statistics
DOI: https://doi.org/10.1007/978-981-10-7826-2
Publisher: Springer Singapore
eBook Packages: Mathematics and Statistics, Mathematics and Statistics (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-10-7825-5Published: 31 August 2018
Softcover ISBN: 978-981-13-4007-9Published: 10 January 2019
eBook ISBN: 978-981-10-7826-2Published: 21 August 2018
Series ISSN: 2199-0980
Series E-ISSN: 2199-0999
Edition Number: 1
Number of Pages: XIII, 245
Number of Illustrations: 16 b/w illustrations, 18 illustrations in colour
Topics: Statistics for Life Sciences, Medicine, Health Sciences, Biostatistics