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Circadian Pharmacokinetics

  • Book
  • © 2020

Overview

Editors:
  1. Baojian Wu

    1. Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, Guangzhou, China

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  2. Danyi Lu

    1. Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, Guangzhou, China

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    You can also search for this editor in PubMed   Google Scholar

  3. Dong Dong

    1. School of Medicine, Jinan University, Guangzhou, China

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  • Reinforces basic knowledge and principles on circadian clock and metabolic diseases

  • Enriches understanding of circadian regulation of drug metabolism and transport

  • Serves as a helpful reference and provides implications of circadian pharmacokinetics in chronotherapeutics

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-vii
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  2. Introduction to Mammalian Circadian Clock System

    • Mengjing Zhao, Danyi Lu, Min Chen, Baojian Wu
    Pages 1-21

  3. Introduction to Pharmacokinetics

    • Mengjing Zhao, Yi Wang, Min Chen, Baojian Wu
    Pages 23-40

  4. Circadian Clock and Metabolic Diseases

    • Shuai Wang, Feng Li, Ziyue Zhou, Zemin Yang, Jingpan Lin, Dong Dong
    Pages 41-63

  5. Circadian Clock and CYP Metabolism

    • Tianpeng Zhang, Fangjun Yu, Lianxia Guo, Dong Dong
    Pages 65-87

  6. Circadian Clock and Non-CYP Phase I Metabolism

    • Min Chen, Tianpeng Zhang, Danyi Lu, Baojian Wu
    Pages 89-111

  7. Circadian Clock and Phase II Metabolism

    • Lianxia Guo, Dong Dong, Tianpeng Zhang, Baojian Wu
    Pages 113-129

  8. Circadian Clock and Uptake Transporters

    • Danyi Lu, Menglin Chen, Yi Wang, Min Chen, Baojian Wu
    Pages 131-158

  9. Circadian Clock and Efflux Transporters

    • Danyi Lu, Huan Zhao, Baojian Wu
    Pages 159-186

  10. Role of Pharmacokinetics in Chronotherapeutics

    • Danyi Lu, Yi Wang, Menglin Chen, Huan Zhao, Dong Dong
    Pages 187-237

  11. Role of Non-Pharmacokinetic Factors in Chronoefficacy

    • Shuai Wang, Yanke Lin, Lu Gao, Zemin Yang, Dong Dong
    Pages 239-253
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Keywords

About this book

This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book's contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.

Editors and Affiliations

  • Research Center for Biopharmaceutics and Pharmacokinetics, College of Pharmacy, Jinan University, Guangzhou, China

    Baojian Wu, Danyi Lu

  • School of Medicine, Jinan University, Guangzhou, China

    Dong Dong

About the editors

Dr. Baojian Wu is a professor at the College of Pharmacy, Jinan University, China. He obtained his Ph.D. from University of Houston in 2011 and completed his post-doctoral training at the Baylor College of Medicine from 2011 to 2012. His research focuses on circadian regulation of drug metabolism and transport, as well as circadian regulation of inflammatory and metabolic diseases, fields in which he has published more than 100 research articles.

Dr. Danyi Lu is an associate professor at the College of Pharmacy, Jinan University, China.

Dr. Dong Dong is an associate professor at the College of Medicine, Jinan University, China..


Bibliographic Information

  • Book Title: Circadian Pharmacokinetics

  • Editors: Baojian Wu, Danyi Lu, Dong Dong

  • DOI: https://doi.org/10.1007/978-981-15-8807-5

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2020

  • Hardcover ISBN: 978-981-15-8806-8Published: 29 October 2020

  • Softcover ISBN: 978-981-15-8809-9Published: 29 October 2021

  • eBook ISBN: 978-981-15-8807-5Published: 28 October 2020

  • Edition Number: 1

  • Number of Pages: VII, 253

  • Number of Illustrations: 13 b/w illustrations, 46 illustrations in colour

  • Topics: Pharmacology/Toxicology, Pharmacy, Biomedicine, general

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