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Co-signal Molecules in T Cell Activation

Immune Regulation in Health and Disease

  • Book
  • © 2019

Overview

Editors:
  1. Miyuki Azuma

    1. Department of Molecular Immunology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Hideo Yagita

    1. Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Explains the basic concepts and roles of co-signal molecules
  • Discusses applied and clinical studies using co-stimulation mechanisms
  • Presents a variety of potential therapeutic applications

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1189)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vi
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  2. Basic Understanding of Co-signal Molecules in T Cell Activation

    1. Front Matter

      Pages 1-1
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    2. Co-signal Molecules in T-Cell Activation

      • Miyuki Azuma
      Pages 3-23

    3. The CD28–B7 Family of Co-signaling Molecules

      • Shigenori Nagai, Miyuki Azuma
      Pages 25-51

    4. The TNF–TNFR Family of Co-signal Molecules

      • Takanori So, Naoto Ishii
      Pages 53-84

    5. Signal Transduction Via Co-stimulatory and Co-inhibitory Receptors

      • Shuhei Ogawa, Ryo Abe
      Pages 85-133

    6. Molecular Dynamics of Co-signal Molecules in T-Cell Activation

      • Takashi Saito
      Pages 135-152

    7. Role of Co-stimulatory Molecules in T Helper Cell Differentiation

      • Michelle Schorer, Vijay K. Kuchroo, Nicole Joller
      Pages 153-177

    8. Control of Regulatory T Cells by Co-signal Molecules

      • James Badger Wing, Christopher Tay, Shimon Sakaguchi
      Pages 179-210

  3. Co-signal Molecules in Health and Disease

    1. Front Matter

      Pages 211-211
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    2. Stimulatory and Inhibitory Co-signals in Autoimmunity

      • Taku Okazaki, Il-mi Okazaki
      Pages 213-232

    3. Co-signaling Molecules in Neurological Diseases

      • Pia Kivisäkk, Samia J. Khoury
      Pages 233-265

    4. Costimulation Blockade in Transplantation

      • Melissa Y. Yeung, Tanja Grimmig, Mohamed H. Sayegh
      Pages 267-312

    5. Cancer Immunotherapy Targeting Co-signal Molecules

      • Masao Nakajima, Koji Tamada
      Pages 313-326
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Keywords

About this book

This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated.Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.   


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Editors and Affiliations

  • Department of Molecular Immunology Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

    Miyuki Azuma

  • Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan

    Hideo Yagita

About the editors

Miyuki Azuma
Tokyo Medical and Dental University, Grad Sch of Medical and Dental Sciences, Japan


Hideo Yagita
Juntendo University School of Medicine, Dept of Immunology, Japan  

Bibliographic Information

  • Book Title: Co-signal Molecules in T Cell Activation

  • Book Subtitle: Immune Regulation in Health and Disease

  • Editors: Miyuki Azuma, Hideo Yagita

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-32-9717-3

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-32-9716-6Published: 12 December 2019

  • Softcover ISBN: 978-981-32-9719-7Published: 31 December 2020

  • eBook ISBN: 978-981-32-9717-3Published: 22 November 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VI, 326

  • Number of Illustrations: 1 b/w illustrations, 21 illustrations in colour

  • Topics: Immunology, Cancer Research, Neurology, Oncology

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