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Introduction to Basics of Pharmacology and Toxicology

Volume 2 : Essentials of Systemic Pharmacology : From Principles to Practice

  • Describes the pharmacology of drugs acting on different systems in the human body
  • Analyses various human diseases and the pharmacological agents governing them
  • Provides a valuable reference resource for academicians, researchers, and clinical practitioners

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Table of contents (70 chapters)

  1. Front Matter

    Pages i-xxiv
  2. Autonomic Nervous System

    1. Front Matter

      Pages 1-1
    2. Cholinoceptor Agonists and Anticholinesterase Agents

      • Mageshwaran Lakshmanan
      Pages 3-24
    3. Cholinoceptor Antagonists

      • Mageshwaran Lakshmanan
      Pages 25-40
    4. Adrenergic Agonists

      • Abialbon Paul
      Pages 41-53
    5. Adrenergic Antagonists

      • Abialbon Paul
      Pages 55-65
  3. Central and Peripheral Nervous System

    1. Front Matter

      Pages 67-67
    2. Neurotransmitters and Neurotransmission

      • Elavarasi Pichai, Mageshwaran Lakshmanan
      Pages 69-95
    3. Hypnotics and Sedatives

      • Kiruthika Sivagourounadin
      Pages 97-129
    4. Pharmacotherapy of Seizures

      • Saranya Vilvanathan
      Pages 131-151
    5. General Anesthetics

      • Shanthi Paulraj, Mageshwaran Lakshmanan
      Pages 153-178
    6. Drug Therapy of Psychosis and Mania

      • Avinash Arivazhahan
      Pages 179-192
    7. Pharmacotherapy of Depression and Anxiety Disorders

      • Sadhana N. Holla, Avinash Arivazhahan
      Pages 193-204
    8. Pharmacotherapy of Neurodegenerative Disorders

      • Neel Jayesh Shah
      Pages 205-212
    9. Opioid Agonists and Antagonists

      • Shathish Kumar, Soumya Itagi
      Pages 213-235
    10. Drug Dependence and Abuse

      • Neel Jayesh Shah
      Pages 247-253
    11. Local Anesthetics

      • Avinash Arivazhahan
      Pages 255-270
    12. Skeletal Muscle Relaxants

      • Alphienes Stanley Xavier
      Pages 271-280
  4. Autacoids and Other Chemical Mediators

    1. Front Matter

      Pages 281-281

About this book

This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics.

Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. 

This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences. 

Editors and Affiliations

  • Department of Pharmacology & Clinical Skills, Medical University of the Americas, Nevis, Saint Kitts and Nevis

    Abialbon Paul

  • Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, India

    Nishanthi Anandabaskar

  • Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India

    Jayanthi Mathaiyan

  • Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Bibinagar, Hyderabad Metropolitan Region, India

    Gerard Marshall Raj

About the editors

Dr. Abialbon Paul completed his M.B.B.S. and M.D. in Pharmacology from Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER). He finished M.B.B.S. with distinction and four gold medals. Currently, he is working as an Assistant Professor of Pharmacology. During his post-graduation, he has been extremely passionate about teaching and research. The editor has been actively involved in the conduction of ethics committee meetings. He has published research articles and reviews in indexed journals and acted as a resource person/ faculty and organizing committee member of various academic programs including conferences, workshops and CMEs. He has been the Clinical Pharmacologist in-charge of the Madurai region of Apollo Hospitals where he had developed Antibiotic Stewardship programs and took charge of the medication management. 

Dr. Nishanthi Anandabaskar has finished her M.B.B.S. and M.D. in Pharmacology from JIPMER, Puducherry.  Currently, she is working as an Assistant Professor in the Dept. of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital (SMVMCH), Puducherry, India. She was awarded the Prof. M.N. Ghosh gold medal (2017) for outstanding performance in Pharmacology. She has also completed the Postgraduate Diploma in Bioethics (PGDBE) from the PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India. She is a member of the Institutional Ethics Committee of SMVMCH, Puducherry and also of the Institutional Ethics Committee for observational studies in JIPMER, Puducherry, India. The editor has co-authored a book chapter on “Precision medicine in diabetes mellitus” in the book “Precision Medicine in Cancers and Non-Communicable Diseases” (CRC Press; ISBN: 9781315154749). She has also completed online certificate courses on Professional Diploma in Clinical Research (PDCR) and Advance Certificate Course in Scientific Writing from the Catalyst Clinical Services. Dr.Nishanthi has published research papers in Pharmacology in leading national and international biomedical journals.

Dr. Jayanthi Mathaiyan, M.B.B.S., M.D., D.N.B., is currently working as a faculty (Additional Professor and Head, Dept. of Pharmacology) at JIPMER involved in teaching, research and administrative activities. Dr. Jayanthi  has a teaching experience of over a decade which includes taking lectures, question paper setting and evaluation of medical (M.B.B.S., M.D. Pharmacology), paramedical (B.Sc. Nursing, Medical Lab Technology and related courses) students, conducting orientation programmes to M.B.B.S., M.D. and Ph.D. students. Research activities include conducting & guiding M.B.B.S., M.D. and Ph.D. students for research in areas of interest. She has been involved in research in the fields of rational use of medicines, medication errors, pharmacogenomics and therapeutic drug monitoring for over 10 years. She has guided numerous projects involving research in the areas of medication errors with anticancer drug use, pharmacogenomics of diazepam, metformin and capecitabine. She has co-authored 30 indexed journal publications, both national and international and has also contributed chapters in medical books.


Dr. Gerard Marshall Raj holds an M.B.B.S. and M.D. in Pharmacology. Currently, he is working as an Assistant Professor in the Dept. of Pharmacology, All India Institute of Medical Sciences (AIIMS), Bibinagar, Hyderabad Metropolitan Region, Telangana, India. He has contributed and co-edited the book ‘Introduction to Basics of Pharmacology and Toxicology Volume 1: General and Molecular Pharmacology: Principles of Drug action’ (Springer-Nature; ISBN: 9789813297784). He has also contributed book chapters in other books, namely, ‘Intellectual Property Rights in Drug Development and Biotechnology’ in the book ‘Intellectual Property Issues in Biotechnology’ (CABI; ISBN: 9781780646534), ‘Intellectual Property Issues Surrounding Antimicrobial Agents’ in the book ‘Intellectual Property Issues in Microbiology’ (Springer-Nature; ISBN: 9789811374654), and ‘The Pharmacogenetics of Metformin’ in the book ‘The Pharmacological Guide to Metformin’ (Nova Science Publishers; ISBN: 9781536166347). He was awarded the ‘Prof. M. N. Ghosh Gold Medal’ for outstanding performance during the M.D. Pharmacology course at JIPMER, Puducherry and has published many research articles, reviews, commentaries, case reports, and letters-to-the-editor in peer-reviewed and indexed journals.

Bibliographic Information

  • Book Title: Introduction to Basics of Pharmacology and Toxicology

  • Book Subtitle: Volume 2 : Essentials of Systemic Pharmacology : From Principles to Practice

  • Editors: Abialbon Paul, Nishanthi Anandabaskar, Jayanthi Mathaiyan, Gerard Marshall Raj

  • DOI: https://doi.org/10.1007/978-981-33-6009-9

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2021

  • Hardcover ISBN: 978-981-33-6008-2Published: 15 March 2021

  • Softcover ISBN: 978-981-33-6011-2Published: 16 March 2022

  • eBook ISBN: 978-981-33-6009-9Published: 13 March 2021

  • Edition Number: 1

  • Number of Pages: XXIV, 1175

  • Number of Illustrations: 35 b/w illustrations, 117 illustrations in colour

  • Topics: Pharmacology/Toxicology, Pharmacy, Drug Resistance, Vaccine, Neurosciences

Buy it now

Buying options

eBook USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access