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Targeted Learning

Causal Inference for Observational and Experimental Data

By Mark J. van der Laan , Sherri Rose

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As the size of data sets grows ever larger, the need for valid statistical tools is greater than ever. This book introduces super learning and the targeted maximum likelihood estimator, and discusses complex data structures and related applied topics.

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  • ISBN13: 978-1-4419-9781-4
  • 697 Pages
  • Publication Date: June 17, 2011
  • Available eBook Formats: PDF
Full Description
The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest.   This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.
Table of Contents

Table of Contents

  1. Models, Inference, and Truth.
  2. The Open Problem.
  3. Defining the Model and Parameter.
  4. Super Learning.
  5. Introduction to TMLE.
  6. Understanding TMLE.
  7. Why TMLE?.
  8. Bounded Continuous Outcomes.
  9. Direct Effects and Effect Among the Treated.
  10. Marginal Structural Models.
  11. Positivity.
  12. Robust Analysis of RCTs Using Generalized Linear Models.
  13. Targeted ANCOVA Estimator in RCTs.
  14. Independent Case
  15. Control Studies.
  16. Why Match? Matched Case
  17. Control Studies.
  18. Nested Case
  19. Control Risk Score Prediction.
  20. Super Learning for Right
  21. Censored Data.
  22. RCTs with Time
  23. to
  24. Event Outcomes.
  25. RCTs with Time
  26. to
  27. Event Outcomes and Effect Modification Parameters.
  28. C
  29. TMLE of an Additive Point Treatment Effect.
  30. C
  31. TMLE for Time
  32. to
  33. Event Outcomes.
  34. Propensity
  35. Score
  36. Based Estimators and C
  37. TMLE.
  38. Targeted Methods for Biomarker Discovery.
  39. Finding Quantitative Trait Loci Genes.
  40. Case Study: Longitudinal HIV Cohort Data.
  41. Probability of Success of an In Vitro Fertilization Program.
  42. Individualized Antiretroviral Initiation Rules.
  43. Cross
  44. Validated Targeted Minimum
  45. Loss
  46. Based Estimation.
  47. Targeted Bayesian Learning.
  48. TMLE in Adaptive Group Sequential Covariate Adjusted RCTs.
  49. Foundations of TMLE.
  50. Introduction to R Code Implementation.

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