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Computational Biology

Computing for Comparative Microbial Genomics

Bioinformatics for Microbiologists

Authors: Ussery, David Wayne, Wassenaar, Trudy M., Borini, Stefano

  • Teaches computational / bioinformatic methods for comparison of microbial genomes
  • Contains detailed examples of comparisons at the level of DNA, RNA and protein, in terms of structure and functional analysis
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eBook $69.99
price for USA
  • ISBN 978-1-84800-255-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Download immediately after purchase
Hardcover $89.95
price for USA
  • ISBN 978-1-84800-254-8
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $89.95
price for USA
  • ISBN 978-1-84996-763-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this Textbook

The major difficulty many microbiologists face is simply that of too much information. As a result of sequencing technologies becoming so economical, there is a very real and pressing need for high-throughput computational methods to compare hundreds and thousands of bacterial genomes.

This accessible text/reference provides a coherent set of tools and a methodological framework for comparing raw DNA sequences and fully annotated genome sequences, then using these to build up and test models about groups of interacting organisms within an environment or ecological niche. Easy-to-follow, this introductory textbook is built around teaching computational / bioinformatics methods for comparison of microbial genomes, and includes detailed examples of how to compare them at the level of DNA, RNA, and protein, in terms of structural and functional analysis.

Topics and Features:

• Contains five introductory chapters each representing a specific scientific field, to bring all readers up to the same basic level

• Familiarizes readers with genome sequences, RNA sequences (transcriptomics), proteomics and regulation of gene expression

• Describes basic methods to compare genomes and visualize the results for easy interpretation

• Discusses microbial communities, providing a framework for analysing and comparing individual genomes or raw DNA derived from complete ecosystems

• Introduces various atlases, building up to the Genome Atlas

• Offers numerous helpful examples throughout

• Focuses on the use and interpretation of publicly available Web tools

• Provides supplemental resources, such as Web links, at http://comparativemicrobial.com

Developed from a set of lectures for a course in Comparative Microbial Genomics taught since 2001, this wide-ranging foundational textbook is aimed at advanced undergraduate and graduate students in Bioinformatics and Microbiology. The authors are from diverse backgrounds complementing the interdisciplinary nature of the topic and consequently have developed a common scientific language. Readers will find this text an invaluable reference for computational and bioinformatics tools.

Reviews

From the reviews:

"It is a very well-written review of genomics and proteomics of microbes, and makes convincing arguments for the practicality of applying bioinformatics to the study of communities of these species. The references are well chosen. The writing style is superb. … There is an amazing amount of interesting material, in fewer than 275 pages. … The book is probably more suitable as an introduction to contemporary applications of bioinformatics and microbiology for computational scientists." (Anthony J. Duben, ACM Computing Reviews, June, 2009)


Table of contents (4 chapters)

  • Sequences as Biological Information: Cells Obey the Laws of Chemistry and Physics

    David W. Ussery PhD, Trudy M. Wassenaar PhD, Stefano Borini PhD

    Pages 3-17

  • Bioinformatics for Microbiologists: An Introduction

    David W. Ussery PhD, Trudy M. Wassenaar PhD, Stefano Borini PhD

    Pages 19-35

  • Transcriptomics: Translated and Untranslated RNA

    David W. Ussery PhD, Trudy M. Wassenaar PhD, Stefano Borini PhD

    Pages 153-166

  • Microbial Communities: Core and Pan-Genomics

    David W. Ussery PhD, Trudy M. Wassenaar PhD, Stefano Borini PhD

    Pages 213-228

Buy this book

eBook $69.99
price for USA
  • ISBN 978-1-84800-255-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Download immediately after purchase
Hardcover $89.95
price for USA
  • ISBN 978-1-84800-254-8
  • with online files
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $89.95
price for USA
  • ISBN 978-1-84996-763-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Computing for Comparative Microbial Genomics
Book Subtitle
Bioinformatics for Microbiologists
Authors
Series Title
Computational Biology
Series Volume
8
Copyright
2009
Publisher
Springer-Verlag London
Copyright Holder
Springer-Verlag London
eBook ISBN
978-1-84800-255-5
DOI
10.1007/978-1-84800-255-5
Hardcover ISBN
978-1-84800-254-8
Softcover ISBN
978-1-84996-763-1
Series ISSN
1568-2684
Edition Number
1
Number of Pages
XIV, 270
Topics