Computational Biology

Frontiers in Computational and Systems Biology

Editors: Feng, Jianfeng, Fu, Wenjiang, Sun, Fengzhu (Eds.)

  • Presents thermodynamic models for analyzing gene regulatory mechanisms
  • Reviews major algorithms for RNA secondary structure prediction
  • Examines application of models of stochastic processes in nonequilibrium thermodynamics and biological signal transduction
see more benefits

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-84996-196-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA
  • ISBN 978-1-84996-195-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA
  • ISBN 978-1-4471-2570-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

Biological and biomedical studies have entered a new era due to the widespread use of mathematical models and computational approaches. What was no more than a theoretician's fantasy 20 years ago has become the blooming field of computational biology. Furthermore, this powerful and stimulating research paradigm in biological studies has in turn led to new developments in mathematics, physics and computer science.

This unique volume surveys state-of-the-art research on statistical methods in molecular and systems biology, with contributions from leading experts in the field. Each chapter discusses theoretical aspects, applications to biological problems, and possible future developments. Understanding the biology at a molecular and system level stands among the most exciting challenges faced by modern science. This text clearly demonstrates how computational and mathematical approaches continue to address this challenge.

Topics and features:

  • Presents the use of thermodynamic models to analyze gene regulatory mechanisms
  • Reviews major algorithms for RNA secondary structure prediction, with a focus on ensemble-based approaches
  • Discusses how developments in the area of oligo arrays has led to a better understanding of the array mechanism and improvements in microarray data analysis
  • Examines the application of models of stochastic processes in nonequilibrium thermodynamics and biological signal transduction
  • Describes phylogenetic footprinting methods for TFBS identification, based on alignments
  • Introduces penalized regression-based methods for constructing genetic interaction or regulatory networks
  • Investigates the specific role played by irreversible Markov processes in modeling cellular biochemical systems
  • Explores the concept of gene modules in a transcriptional regulatory network

With reviews of current hot topics in computational biology and systems biology, supplied by an international selection of top researchers, this is an essential text for researchers and graduate students in computational biology, biology and mathematics.

Reviews

From the reviews:

“This mosaic of reviews and research precisely reflects the dynamic field of computational and systems biology. All of the major organizational levels of life are represented … . Each chapter has a brief introduction to a biological subject, a review of the main mathematical and statistical models for that particular topic, and a description of the main applications and conclusions. There are an abundant number of references for each chapter. … This compilation … is likely to inspire generations of students, researchers, and readers.” (Adrian Pasculescu, ACM Computing Reviews, January, 2011)

Table of contents (19 chapters)

  • Analysis of Combinatorial Gene Regulation with Thermodynamic Models

    Chen, Chieh-Chun (et al.)

    Pages 1-17

  • RNA Secondary Structure Prediction and Gene Regulation by Small RNAs

    Ding, Ye

    Pages 19-37

  • Some Critical Data Quality Control Issues of Oligoarrays

    Fu, Wenjiang J. (et al.)

    Pages 39-59

  • Stochastic-Process Approach to Nonequilibrium Thermodynamics and Biological Signal Transduction

    Ge, Hao

    Pages 61-81

  • Granger Causality: Theory and Applications

    Guo, Shuixia (et al.)

    Pages 83-111

Buy this book

eBook $149.00
price for USA (gross)
  • ISBN 978-1-84996-196-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA
  • ISBN 978-1-84996-195-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Softcover $169.99
price for USA
  • ISBN 978-1-4471-2570-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Bibliographic Information

Bibliographic Information
Book Title
Frontiers in Computational and Systems Biology
Editors
  • Jianfeng Feng
  • Wenjiang Fu
  • Fengzhu Sun
Series Title
Computational Biology
Series Volume
15
Copyright
2010
Publisher
Springer-Verlag London
Copyright Holder
Springer-Verlag London Limited
eBook ISBN
978-1-84996-196-7
DOI
10.1007/978-1-84996-196-7
Hardcover ISBN
978-1-84996-195-0
Softcover ISBN
978-1-4471-2570-9
Series ISSN
1568-2684
Edition Number
1
Number of Pages
XXV, 24
Topics